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Primer3

The reference primer design engine, still the one to beat.

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Primer3

Whitehead Institute · primer3.ut.ee

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The reference primer design engine, still the one to beat.
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Use this when

Standard PCR primer design. Use NCBI Primer-BLAST when specificity against a whole genome matters more than fine parameter control.

Open Primer3

External tool. We link, we don’t host — nothing you enter on Biology 101 reaches them.

About this tool

Designs PCR primers with full control over Tm, GC, product size, self-complementarity and mispriming against a background set.

Science last reviewed .