I ran thousands of tests — which results are real?
Correct for multiple testing
Bonferroni, Benjamini–Hochberg, and choosing between them.
Testing 20,000 genes at p < 0.05 gives you around 1,000 false positives before any biology happens. Bonferroni controls the chance of even one false positive and is severe; it suits a handful of pre-planned comparisons. Benjamini–Hochberg controls the proportion of false positives among your hits and is the standard for genomics, where a 5% false discovery rate in a hit list is an acceptable trade.
Report adjusted values and say which method produced them. "q < 0.05" and "p < 0.05" are different claims.